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Thermo Scientific™ Tango™ EDNRA-bla U2OS Cells
The Tango™ EDNRA-bla U2OS cells contain the human Endothelin Receptor A (EDNRA) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tango™ GPCR-bla U2OS parental cell line.
Marca: Thermo Scientific™
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Descripción
The Tango™ EDNRA-bla U2OS cells contain the human Endothelin Receptor A (EDNRA) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tango™ GPCR-bla U2OS parental cell line. This parental cell line stably expresses a beta-arrestin/TEV protease fusion protein and the beta-lactamase (bla) reporter gene under the control of a UAS response element.
The Tango™ EDNRA-bla U2OS cell line has been functionally validated for Z'-factor and EC50 concentrations of ET-1. The EDNRA cells have been tested for assay performance under variable assay conditions. These data are available in the Validation & Assay Performance Summary in the Manuals and Brochures section.
Endothelin receptor type A (ENDRA) mediates signaling of endothelin proteins that regulate several critical biological processes, including development and function of blood vessels, production of certain hormones, and stimulation of cell growth and division. Defects in EDNRA-mediated signaling have been implicated in a wide range of diseases, including cancer, hypertension, and cardiovascular disorders.
Especificaciones
| NM_001957 | |
| Células divisoras | |
| Cola de AVPR2 GPCR | |
| GPCR | |
| Células EDNRA-bla U2OS, protocolo de ensayo EDNRA-bla U2OS, certificado de análisis | |
| Tango™ | |
| BLA (betalactamasa) | |
| EDNRA | |
| U2OS | |
| GPCR |
| Selección de arrestina beta basada en células | |
| (Kit de carga LiveBLAzer™-FRET B/G, solución D y otros materiales se requieren por separado; consulte el protocolo). Incluye: o Células Tango™ EDNRA-bla U2OS o Protocolo de ensayo Tango™ EDNRA-bla U2OS o Certificados de análisis Las células Tango™ EDNRA-bla U2OS se envían en hielo seco. Transferir a nitrógeno líquido inmediatamente después de su recepción, o descongelar para su uso inmediato. |
|
| Fluorescente | |
| EDNRA | |
| Conjunto de células estables | |
| 2 x 106 células | |
| Temperatura ambiente | |
| Células en proceso de división | |
| Tango™ |
Para uso exclusivo en investigación. No apto para uso en procedimientos diagnósticos.