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Tocris Bioscience™ Targapremir 210
Inhibits formation of miR-210
Marca: Tocris Bioscience™ 6586/5
Detalles adicionales : Peso : 0.00970kg
Descripción
Targapremir 210 inhibits formation of mature miR-210 (IC50 = 200 nM) by binding to Dicer binding site of the miR-210 hairpin precursor (Kd = 200 nM) and inhibits Dicer processing of the miRNA. Decreases levels of miR-210 and HIF-1α mRNA, and induces apoptosis in MDA-MB-231 cells cultured under hypoxic conditions. Reduces tumor expression of HIF-1α mRNA and miR-210, and tumor growth in a triple negative breast cancer mouse model.Especificaciones
| N-(3-Azidopropyl)-4-[3-[6-(4-methyl-1-piperazinyl)[2,6'-bi-1H-benzimidazol]-2'-yl]phenoxy]butanamide | |
| 5 mg | |
| 98% |
| 1049722-30-6 | |
| C32H36N10O2 |