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Topotecan hydrochloride, Tocris Bioscience™
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Cantidad:
10 mg
50 mg
Descripción
Topotecan hydrochloride is a DNA topoisomerase I inhibitor; induces rapid apoptotic death in human B-lineage acute lymphoblastic leukemia (ALL) cells. Improves survival in three mouse models of poor prognosis ALL; downregulates B-Myb and MycN expression in neuroblastoma cells. Water-soluble analog of Camptothecin (Cat. No. 1100). Orally bioavailable. Topotecan disrupts the interaction between NHP2L1 and U4 RNA by binding to U4 and inhibits RNA splicing.
Especificaciones
Nombre del producto químico o material | Topotecan hydrochloride |
Cantidad | 10 mg |
Formula Weight (peso de la fórmula) | 457.91 |
Porcentaje de pureza | >98% |
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