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Eurofins DiscoverX TYK2 Protein, Active
Active, TN-terminal 6His-tagged, recombinant, human TYK2, amino acids 875-end, for use in Kinase Assays.
Marca: Eurofins DiscoverX 14-924
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Descripción
TYK2 is member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
GenBank NM_003331
Especificaciones
| mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. | |
| 10 μg | |
| Recombinant | |
| Recombinant enzyme expressed in Sf21 insect cells | |
| ≥67% |
| 40 kDa | |
| Human | |
| N-terminal 6His | |
| Truncated | |
| TYK2, active |