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Eurofins DiscoverX ULK3 Protein, Active
Active, N-terminal 6His-tagged recombinant human full-length ULK3, for use in Kinase Assays.
Marca: Eurofins DiscoverX 14-755
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Descripción
ULK3 (Unc-51 Like Kinase 3) is a Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. It acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). It also positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. ULK3 Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
GenBank XM_044630 (DNA has been codon optimized for insect cell expression)
Especificaciones
| mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1 mM EGTA, 0.1% 2-mercaptoethanol, 0.03% Brij-35. Frozen solution. | |
| 10 μg | |
| Recombinant | |
| Recombinant enzyme expressed in Sf21 insect cells | |
| ≥73% |
| 62 kDa | |
| Human | |
| N-terminal 6His | |
| Full-length | |
| ULK3, active |