Los anticuerpos son glicoproteínas que desempeñan un papel esencial en el sistema inmunitario para proteger a los animales de infecciones o los efectos citotóxicos de compuestos extraños, mediante la unión con alta afinidad a moléculas invasivas; se clasifican como primarios o secundarios.
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For low background screening on a variety of mouse and human tissues. anti-IgG1 κ Mouse, R-PE, Clone: MOPC-21, Isotype Control, BD immunoglobulin is a mouse myeloma protein. This antibody is routinely tested by flow cytometric analysis.
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This MAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.
Highly species-specific anti-Mouse IgG. Cytiva Lifescience™ anti-Mouse IgG, peroxidase-linked species-specific whole antibody (from sheep) Secondary Antibody is designed for applications such as protein blotting, ELISA and immunocytochemistry.
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