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Tocris Bioscience™ AMG 510
Potent and selective KRASG12C inhibitor
Marca: Tocris Bioscience™ 7713/10
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Descripción
AMG 510 is a potent and selective covalent KRASG12C inhibitor (IC50 = 90 nM). Also a potent inhibitor of phospho-ERK (IC50 = 68 nM). In an in vivo model of non-small cell lung cancer, AMG 510 causes regression of tumors, an increase in T-cell recruitment and a pro-inflammatory tumor microenvironment. Synergises with MEK inhibitors and Carboplatin (Cat. No. 2626) and is orally bioavailable.Especificaciones
| (1 R)-6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2 S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1 H)-one | |
| 10 mg | |
| C30H30F2N6O3 |
| 2252403-56-6 | |
| Ras GTPase Inhibitors | |
| 0.98 |