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STEMCELL Technologies AZD6244
MEK/ERK pathway inhibitor; Inhibits MEK1 and MEK2
Brand: STEMCELL Technologies 72994
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Description
- AZD6244 is a potent, highly selective inhibitor of the mitogen-activated protein kinases MEK1 (IC50 = 14 nM) and MEK2 (Kd = 530 nM; Yeh et al.; Davis et al.) It is a tight-binding noncompetitive inhibitor that does not bind in the ATP binding pocket of MEK (Huynh et al.) It also shows micromolar binding to epidermal growth factor receptor (EGFR; Davis et al.)
- Inhibits growth of several tumor cell lines but not normal fibroblast lines, and inhibits tumor growth in a colorectal xenograft tumor model (Yeh et al.)
- Inhibits proliferation and induces differentiation and apoptosis in multiple tumor cell lines and tumor xenograft models, especially those containing BRAF or RAS mutations (Davies et al.)
- Inhibits proliferation of breast cancer and non-small cell lung cancer cell lines, especially those containing RAF and RAS mutations, respectively (Garon et al.)
Specifications
| 606143-52-6 | |
| 50 mg | |
| ≥98% |
| ARRY-142886; Cl-1040; NSC 741O78; Selumetinib; G 00039805 | |
| C17H15BrClFN4O3 |