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STEMCELL Technologies AZD6244
MEK/ERK pathway inhibitor; Inhibits MEK1 and MEK2
68.85€ - 120.15€
| Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
|---|---|---|---|---|---|---|---|---|---|
| Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
17180152
|
STEMCELL Technologies
72992 |
10 mg |
68.85€
10 miligramos |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | |||||
|
17190152
|
STEMCELL Technologies
72994 |
50 mg |
120.15€
50 miligramos |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | |||||
Descripción
- AZD6244 is a potent, highly selective inhibitor of the mitogen-activated protein kinases MEK1 (IC50 = 14 nM) and MEK2 (Kd = 530 nM; Yeh et al.; Davis et al.) It is a tight-binding noncompetitive inhibitor that does not bind in the ATP binding pocket of MEK (Huynh et al.) It also shows micromolar binding to epidermal growth factor receptor (EGFR; Davis et al.)
- Inhibits growth of several tumor cell lines but not normal fibroblast lines, and inhibits tumor growth in a colorectal xenograft tumor model (Yeh et al.)
- Inhibits proliferation and induces differentiation and apoptosis in multiple tumor cell lines and tumor xenograft models, especially those containing BRAF or RAS mutations (Davies et al.)
- Inhibits proliferation of breast cancer and non-small cell lung cancer cell lines, especially those containing RAF and RAS mutations, respectively (Garon et al.)
Especificaciones
| 606143-52-6 | |
| C17H15BrClFN4O3 |