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CD366 (TIM3) Monoclonal Antibody (F38-2E2), Brilliant Violet™ 605, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Marca: Invitrogen 406-3109-42
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Descripción
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.
Especificaciones
| CD366 (TIM3) | |
| Monoclonal | |
| 5 μL/Test | |
| PBS with BSA and 0.09% sodium azide, pH 7.2 | |
| Q8TDQ0 | |
| Havcr2 | |
| Affinity chromatography | |
| RUO | |
| 84868 | |
| 4°, C, store in dark, DO NOT FREEZE! | |
| IgG1 κ |
| Flow Cytometry | |
| F38-2E2 | |
| Brilliant Violet 605 | |
| Havcr2 | |
| CD366, FLJ14428, Havcr2, HAVcr-2, Hepatitis A virus cellular receptor 2, hepatitis A virus cellular receptor 2 homolog, kidney injury molecule-3, KIM-3, sCD366, soluble CD366, soluble TIM 3, T cell immunoglobulin mucin 3, T cell immunoglobulin mucin-3, T-cell immunoglobulin and mucin domain containing 3, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin family member 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, Tim3, TIM-3, TIMD3, TIMD-3 | |
| Mouse | |
| 100 Tests | |
| Primary | |
| Human | |
| Liquid |
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