missing translation for 'onlineSavingsMsg'
Learn More

Eurofins DiscoverX CDK4/Cyclin D3 Protein, Active

N-terminal GST-tagged, recombinant, human CDK4 full length and N-terminal GST-tagged, recombinant, human cyclin D3 full length co-expressed by baculovirus in Sf21 insect cells. for use in Kinase Assays

Marca:  Eurofins DiscoverX 14-957

Encompass_Preferred

 Ver más versiones de este producto

Código de producto. 17340854

  • 525.15€ / 10 microgramos

Por favor, para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo.

Explore más ofertas especiales
Este artículo no se puede devolver. Vea la política de devoluciones

Descripción

Descripción

CDK4 (Cyclin-dependent kinase 4) forms a complex with type D cyclins such as D1, D2 and D3 and when the cellular levels of cyclin D peak there is a shortening of the G1 phase and rapid entry into S phase of cell cycle progression. The substrate for cdk4/cyclin D is Rb, and phosphorylation of Rb results in dissociation of the E2F complex from Rb. The free E2F proteins in turn stimulate transcription of genes required for DNA synthesis. Cellular inhibition of CDK4/cyclin D3 activity is achieved by its inhibitory proteins, i.e. p16, p21 and p27. Inhibition of CDK4/CCND3 may be used in treatment of uncontrolled cell proliferation, tumor heterogeneity, invasion and metastasis.

GenBank NM_000075.3 / GenBank M90814.1

Especificaciones

Especificaciones

mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% β-mercaptoethanol. Frozen solution.
10 μg
Recombinant
Recombinant enzyme expressed in Sf21 insect cells
Combined ≥72% ratio 2-3:1 CDK4:cyclinD3
61 kDa (CDK4) and 59 kDa (Cyclin D3)
Human
N-terminal GST / N-terminal GST
Full-length
CDK4/Cyclin D3, active
Sugerencias de productos

Sugerencias de productos

Videos
SDS
Documentos

Documentos

Certificados
Ofertas especiales

Ofertas especiales