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Eurofins DiscoverX CDK4/Cyclin D3 Protein, Active
N-terminal GST-tagged, recombinant, human CDK4 full length and N-terminal GST-tagged, recombinant, human cyclin D3 full length co-expressed by baculovirus in Sf21 insect cells. for use in Kinase Assays
525.15€ - 4008.15€
Especificaciones
| Formulación | mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% β-mercaptoethanol. Frozen solution. |
|---|---|
| Peso molecular | 61 kDa (CDK4) and 59 kDa (Cyclin D3) |
| Especie | Human |
| Recombinante | Recombinant |
| Etiqueta de proteína | N-terminal GST / N-terminal GST |
| Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
|---|---|---|---|---|---|---|---|---|---|
| Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
17340854
|
Eurofins DiscoverX
14-957 |
10 μg |
525.15€
10 microgramos |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | |||||
|
17350854
|
Eurofins DiscoverX
14-957M |
250 μg |
4008.15€
250 microgramos |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | |||||
Descripción
CDK4 (Cyclin-dependent kinase 4) forms a complex with type D cyclins such as D1, D2 and D3 and when the cellular levels of cyclin D peak there is a shortening of the G1 phase and rapid entry into S phase of cell cycle progression. The substrate for cdk4/cyclin D is Rb, and phosphorylation of Rb results in dissociation of the E2F complex from Rb. The free E2F proteins in turn stimulate transcription of genes required for DNA synthesis. Cellular inhibition of CDK4/cyclin D3 activity is achieved by its inhibitory proteins, i.e. p16, p21 and p27. Inhibition of CDK4/CCND3 may be used in treatment of uncontrolled cell proliferation, tumor heterogeneity, invasion and metastasis.
GenBank NM_000075.3 / GenBank M90814.1
Especificaciones
| mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% β-mercaptoethanol. Frozen solution. | |
| Human | |
| N-terminal GST / N-terminal GST | |
| Full-length | |
| CDK4/Cyclin D3, active |
| 61 kDa (CDK4) and 59 kDa (Cyclin D3) | |
| Recombinant | |
| Recombinant enzyme expressed in Sf21 insect cells | |
| Combined ≥72% ratio 2-3:1 CDK4:cyclinD3 |