missing translation for 'onlineSavingsMsg'
Learn More
Learn More
DBZ
γ-secretase inhibitor; inhibits Notch pathway
Brand: Tocris Bioscience 4489/50
This item is not returnable.
View return policy
Description
DBZ is an inhibitor of γ-secretase aspartyl protease. DBZ blocks amyloid precursor protein-like (APPL) and Notch cleavage (IC50 values are 2.6 nM and 1.7-2.9 nM, respectively). By inhibiting Notch and the Notch pathway, DBZ improves efficiency of iPSC generation and production of iPSCs from mouse and human keratinocytes without KLF4 and CMYC. In an animal model of Alzheimer's disease, DBZ inhibits the cleavage of amyloid precursor protein into Aβ40. DBZ promotes cochlear supporting cell proliferation and hair cell mitotic regeneration in neonatal mice. DBZ in combination with iDOT1L enables maintenance of human na?ve-state pluripotency in non-hypoxic conditions.DBZ synthesized to Ancillary Material Grade also available.
Specifications
| DBZ | |
| >98% | |
| C26H23F2N3O3 |
| 209984-56-5 | |
| 50 mg | |
| 463.48 |