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Eurofins DiscoverX Lck Protein, Active
Active, N-terminal His6-tagged, recombinant full-length human Lck, for use in Kinase Assays.
Marca: Eurofins DiscoverX 14-442M
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Descripción
The lck protooncogene is a member of the src-related gene family of non-receptor tyrosine kinases. It is uniquely expressed only in T-lymphocytes and NK-cells. The p56lck kinase (LCK) is a 56 KD polypeptide that is associated with a cytoplasmic face of the plasma membrane. It functions as a critical signalling model in IL-2 signal transduction leading to T-lymphocyte activation. Specifically, it has been shown that a stable complex exists between IL-2 receptors and p56lck and that treatment of T-lymphocytes with IL-2 promotes p56lck kinase activity and rapid phosphorylation of cellular substrates. In addition, p56lck has been found to function as a signal transducer for antigen activated CD4 and CG8 T-cell receptors and plays a role in thymic maturation of certain T-cells. The CD45 antigen, a receptor/protein tyrosine phosphatase of T-cells, also interacts with p56lck.
Swiss Prot P06239
Especificaciones
| mg/mL of enzyme in 50 mM Tris/HCl, pH 7.5, 0.1 mM EGTA, 150 mM NaCl, 1 mM benzamidine, 0.03% Brij-35, 0.2 mM PMSF, 0.1% 2-mercaptoethanol, 5% glycerol. Frozen solution. | |
| 250 μg | |
| Recombinant | |
| Recombinant enzyme expressed in Sf21 insect cells | |
| ≥73% |
| 59 kDa | |
| Human | |
| N-terminal 6His | |
| Full-length | |
| Lck, active |