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Eurofins DiscoverX LKB1/STRADα/MO25α Protein, Active
Active, recombinant full-length human LKB1 with an N-terminal 6His tag. Provided as a complex with GST-STRADα and GST-MO25α, for use in Kinase Assays.
Marca: Eurofins DiscoverX 14-596

Descripción
LKB1 is a tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic, and testicular cancers.
GenBank NM000455 / GenBank AF308302 / GenBank NM_016289
Especificaciones
mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. | |
10 μg | |
Recombinant | |
Recombinant enzyme expressed in Sf21 insect cells | |
Combined ≥80% |
52.1 kDa (LKB1), 76.1 kDa (STRADα) and 66.8 kDa (MO25α) | |
Human | |
N-terminal 6His / N-terminal GST / N-terminal GST | |
Full-length | |
LKB1/STRADα/MO25α, active |
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