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Eurofins DiscoverX Lyn Protein, Active
Active, mouse. Recombinant full-length mouse Lyn, containing an N-terminal His6-tag, for use in Kinase Assays.
Marca: Eurofins DiscoverX 14-315
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Descripción
The Lyn protein is a member of the Src family of non-receptor-associated protein-tyrosine kinases. LYN A differs from LYN B in having an additional 21 amino acids at the amino terminus. Lyn undergoes a concentration-dependent autophosphorylation, thus activating the catalytic site and decreasing the accessibility of the SH2 domain. Lyn phosphorylates and activates Tec, non-receptor tyrosine kinase that is coexpressed with Lyn and acts downstream of Lyn in intracellular signaling pathways. Lyn tyrosine kinase has been shown to be necessary for IgE-receptor (FceRI)-mediated mast-cell activation.
EMBL M64608, N425D as reported in SWISS PROT P25911
Especificaciones
| mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 0.1 mM EGTA, 150 mM NaCl, 0.03% Brij-35, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol, 5% glycerol. Frozen solution. | |
| 10 μg | |
| Recombinant | |
| Recombinant enzyme expressed in Sf21 insect cells | |
| ≥66% |
| 60 kDa | |
| Mouse | |
| N-terminal 6His | |
| Full-length | |
| Lyn (mouse), active |