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PCAF Monoclonal Antibody (7D12C8), Invitrogen™
Mouse Monoclonal Antibody
Marca: Thermo Scientific MA538547
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Descripción
This antibody has been tested in indirect ELISA.
PCAF (histone acetyltransferase KAT2B) functions as a histone acetyltransferase (HAT) to promote transcriptional activation. It has significant histone acetyltransferase activity with core histones (H3 and H4) and nucleosome core particles. PCAF also acetylates non-histone proteins such as ACLY, PLK4, and TBX5. It inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. PCAF also acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. It is involved in heart and limb development by mediating acetylation of TBX5 and acetylation regulating nucleocytoplasmic shutting of TBX5.
Especificaciones
| PCAF | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 0.05% sodium azide | |
| Q92831, Q9JHD1 | |
| KAT2B | |
| Purified recombinant fragment of human KAT2B (aa: 1-142) expressed in E. Coli. | |
| 100 μg | |
| Primary | |
| Human, Mouse, Non-human Primate, Rat | |
| Antibody | |
| IgG1 |
| ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot | |
| 7D12C8 | |
| Unconjugated | |
| KAT2B | |
| A930006P13Rik; AI461839; AW536563; CAF; CREBBP-associated factor; histone acetylase PCAF; Histone acetyltransferase KAT2B; histone acetyltransferase PCAF; K(lysine) acetyltransferase 2B; Kat2b; Lysine acetyltransferase 2B; P/ PCAF; P/CAF; P300/CBP-associated factor; Pcaf; Spermidine acetyltransferase KAT2B | |
| Mouse | |
| Protein G | |
| RUO | |
| 18519, 301164, 8850 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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Título del producto
PCAF Monoclonal Antibody (7D12C8), Invitrogen™ > 100 μg; Unconjugated
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