Learn More
FLI-1 Mouse anti-Human, Unlabeled, Clone: G146-254, BD
Mouse Monoclonal Antibody
Marca: BD Biosciences 554267
218.12 EUR hasta el 2025-12-31
Use el código promocional "25339" para aplicar la oferta.
Descripción
Fli-1 is a 50kDa ets-related transcription factor. Like other ets-related proteins it binds to consensus sites in DNA through a 85 amino acid ets domain in the carboxyl region of the protein. Fli-1 is associated with Ewing sarcoma through at (11;22)(q24;q12) chromosomal translocation. This translocation brings the 5' region of the EWS gene into conjunction with the 3' region of the Fli-1 gene encoding the ets-DNA binding domain. Such a translocation is found in 85% of Ewing sarcomas. The resulting fusion protein has the DNA binding activity of Fli-1 and, with the EWS domain, it is also a more potent transcriptional activator than Fli-1 itself. The strong transforming activity of the EWS-Fli-1 fusion protein may in part be due to its ability to trans-activate the promoter for c-myc. C-myc is known to be elevated in Ewing sarcomas. Clone G146-254 was raised against a bacterially expressed Fli-1 ets domain fusion protein.
Host Species: Mouse
Clone: G146-254
Isotype: IgG2a
Species Reactivity: Human
Immunogen: Fli-1 ets Domain Fusion Protein
Formula Weight [Chemical]: 50kDa
Immunoprecipitation, Western Blotting

Especificaciones
FLI-1 | |
Monoclonal | |
0.5mg/mL | |
Aqueous buffered solution containing ≤0.09% sodium azide. | |
Fli-1 ets Domain Fusion Protein | |
0.1 mg | |
Cell Biology | |
Human | |
IgG2a |
Western Blot | |
G146-254 | |
Unconjugated | |
Mouse | |
Affinity Purified | |
RUO | |
Primary | |
Store undiluted at 4°C |
Sugerencias de productos
Los clientes que vieron este artículo también vieron
Proporcione sus comentarios sobre el contenido del producto rellenando el siguiente formulario.
For Research Use Only.