Bmf Polyclonal Antibody, Invitrogen™

Descripción

In Western blot applications, this antibody detects a band at ∽25kDa. A suggested positive control is human kidney tissue lysate. PA5-20002 can be used with blocking peptide PEP-0124.

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified.