Phospho-Caveolin 2 (Tyr19) Polyclonal Antibody, Alexa Fluor™ 488, Invitrogen™

Descripción

PA1-060 detects phospho-caveolin-2 Y19 from human and mouse samples. Immunofluorescent staining of phospho-caveolin-2 Y19 in NIH 3T3 cells using PA1-060-A488 results in a distinct punctate staining pattern at the cell periphery.

Caveolae are specialized domains of the plasma membrane that are implicated in the sequestration of a variety of lipid and protein molecules. It has been suggested that these important cellular organelles have a pivotal role in such diverse biochemical processes as lipid metabolism, growth regulation, signal transduction, and apoptosis. Caveolin interacts with and regulates heterotrimeric G-proteins. Currently, there are three members of the caveolin multigene family which are known to encode 21-24 kDa integral membrane proteins that comprise the major structural component of the caveolar membrane in vivo. Caveolin-2 protein is abundantly expressed in fibroblasts and differentiated adipocytes, smooth and skeletal muscle, and endothelial cells. The expression of caveolin-1 is similar to that of caveolin-2 while caveolin-3 expression appears to be limited to muscle tissue types.