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Gibco™ Human EGF Recombinant Protein

Recombinant Protein

Marca:  Gibco™ PHG0313

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Product Code. 10628523

  • 906.00€ / cada uno

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Description

Description

Carrier-Free Reconstitution: Centrifuge the vial briefly before opening to bring the contents to the bottom. Reconstitute the lyophilized protein in sterile, PBS buffer to a concentration of 0.1-1.0 mg/mL. Make any further dilutions of the reconstituted protein in low endotoxin medium, or a buffered solution containing a carrier protein such as heat inactivated FCS or tissue culture grade BSA Storage: Store the lyophilized protein at 2°C to 8°C, preferably desiccated. Upon reconstitution, apportion into working aliquots and store at ≤-20°C. Avoid repeated freeze-thaw cycles.

EGF (Epidermal growth factor) exerts its actions by binding to the EGF Receptor, a 170 kDa protein kinase. Activation of EGFR initiates diverse cellular pathways in response to toxic environmental stimuli, or to EGF binding to the receptor, the EGFR forms homo- or heterodimers with other family members. Each dimeric receptor complex initiates a distinct signaling pathway by recruiting different Src homology 2 (SH2) containing effector proteins. EGF is far and wide expressed in kidney, cerebrum, prostrate and salivary glands. EGF acts as a potent mitogenic factor and the phosphorylated receptor recruits adapter proteins like GRB2 that activates complex downstream signaling cascades. EGF activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STAT modules. Research studies suggest the protein may also play important role in activating the NF-kappa-B signaling cascade. Defects in the EGGF gene are the cause of hypomagnesemia type 4 and dysregulation has been associated with the growth and progression of certain cancers.
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Número de lote Tipo de certificado Fecha Catalog Number
Número de lote3041581 Tipo de certificadoCertificado de análisis Fecha31/01/2025 Catalog NumberPHG0313
Número de lote2473570 Tipo de certificadoCertificado de análisis Fecha29/01/2025 Catalog NumberPHG0313
Número de lote2490066 Tipo de certificadoCertificado de análisis Fecha29/01/2025 Catalog NumberPHG0313
Número de lote2473571 Tipo de certificadoCertificado de análisis Fecha29/01/2025 Catalog NumberPHG0313
Número de lote2722496 Tipo de certificadoCertificado de análisis Fecha29/01/2025 Catalog NumberPHG0313
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